The series sees Rocky and Bullwinkle "thrust into harrowing situations but end up saving the day time and again. As Rocky and Bullwinkle’s innocent and silly ambitions to become rock stars or find lost treasure end up dovetailing with Fearless Leader’s sinister plans to take over the world, our heroes are set on a collision course with his notorious superspies Boris Badenov and Natasha Fatale."
- Tara Strong as Rocket J. "Rocky" Squirrel
- Brad Norman as Bullwinkle J. Moose
- Ben Diskin as Boris Badenov
- Rachel Butera as Natasha Fatale
- Piotr Michael as Fearless Leader
- Daran Norris as the Narrator