T.U.F.F. Puppy is an American action animated comedy television series created by Butch Hartman for Nickelodeon. It premiered on October 2, 2010, on Nickelodeon along with Planet Sheen. T.U.F.F. Puppy is Butch Hartman's third animated series for Nickelodeon, after The Fairly OddParents (2001–present) and Danny Phantom (2004–2007). The series aired its final episode on April 4, 2015.
- Jerry Trainor as Dudley Puppy
- Grey DeLisle as Kitty Katswell
- Daran Norris as Chief Herbert Dumbrowski / The Chameleon
- Jeff Bennett as Keswick
- Matthew W. Taylor as Verminious Snaptrap
- Rob Paulsen as Bird Brain