The series follows the exploits of the title characters, a 12-year-old boy named Sanjay Patel, and his best friend, an anthropomorphic snake named Craig. On a promotional webpage for the show, the network explains that Sanjay and Craig's suburban hijinks require that "no one finds out that Craig can talk".
- Maulik Pancholy as Sanjay Patel
- Chris Hardwick as Craig Slithers
- Kunal Patel as Vijay Patel
- Grey Griffin as Darlene Patel
- Matt Jones as Hector Flanagan
- Nika Futterman as Belle Pepper
- Linda Cardellini as Megan Sparkles